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Target
Diacylglycerol lipase-beta
Ligand
BDBM434908
Substrate
n/a
Meas. Tech.
In Vitro Inhibition of DAGL
IC50
<400±n/a nM
Citation
 Cravatt, BF; Ogasawara, D; Viader, A; Deng, H; Van Der Wel, T; Van Der Stelt, M Triazole DAGLα inhibitors US Patent  US10583137 Publication Date 3/10/2020 
Target
Name:
Diacylglycerol lipase-beta
Synonyms:
DAGLB | DGLB_HUMAN | Sn1-specific diacylglycerol lipase beta
Type:
PROTEIN
Mol. Mass.:
73731.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557688
Residue:
672
Sequence:
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
  
Inhibitor
Name:
BDBM434908
Synonyms:
(2-benzylpiperidin-1-yl)(4-(4- (4,6-dimethoxypyrimidin-5- yl)phenyl)-1H-1,2,3-triazol-1- yl)methanone | US10583137, Compound 82 | US10583137, Compound 86
Type:
Small organic molecule
Emp. Form.:
C27H28N6O3
Mol. Mass.:
484.5496
SMILES:
COc1ncnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: