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Target
Diacylglycerol lipase-beta
Ligand
BDBM434927
Substrate
n/a
Meas. Tech.
In Vitro Inhibition of DAGL
IC50
<400±n/a nM
Citation
 Cravatt, BF; Ogasawara, D; Viader, A; Deng, H; Van Der Wel, T; Van Der Stelt, M Triazole DAGLα inhibitors US Patent  US10583137 Publication Date 3/10/2020 
Target
Name:
Diacylglycerol lipase-beta
Synonyms:
DAGLB | DGLB_HUMAN | Sn1-specific diacylglycerol lipase beta
Type:
PROTEIN
Mol. Mass.:
73731.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557688
Residue:
672
Sequence:
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
  
Inhibitor
Name:
BDBM434927
Synonyms:
N-cyclobutyl-N-phenethyl-4-(4- (trifluoromethoxy)phenyl)-1H- 1,2,3-triazole-1-carboxamide | US10583137, Compound 124
Type:
Small organic molecule
Emp. Form.:
C22H21F3N4O2
Mol. Mass.:
430.4229
SMILES:
FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)C1CCC1
Structure:
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