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Target
D(3) dopamine receptor
Ligand
BDBM435387
Substrate
n/a
Meas. Tech.
[3H]-Spiperone Binding Assay
Ki
1.26±n/a nM
Citation
 Cremonesi, S; Micheli, F; Semeraro, T; Tarsi, L Substituted 3,6-diazabicyclo[3.2.0]heptanes US Patent  US10584135 Publication Date 3/10/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM435387
Synonyms:
US10584135, Example 218
Type:
Small organic molecule
Emp. Form.:
C25H34F3N5OS
Mol. Mass.:
509.631
SMILES:
Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |w:27.31,31.35,(4.11,.28,;4.29,1.81,;3.17,2.86,;1.68,2.46,;.59,3.55,;-.9,3.15,;-1.99,4.24,;-3.47,3.84,;-4.38,5.09,;-5.84,4.61,;-7.31,5.09,;-8.21,3.84,;-7.31,2.6,;-5.84,3.07,;-4.38,2.6,;-7.79,1.13,;-9.29,.81,;-9.77,-.65,;-8.75,-1.85,;-7.23,-1.48,;-6.75,-.01,;-9.23,-3.32,;-9.71,-4.78,;-10.7,-2.84,;-7.77,-3.79,;3.82,4.26,;5.34,4.07,;5.64,2.56,;7.04,1.91,;7.04,.37,;8.37,-.4,;9.7,.37,;11.04,-.4,;9.7,1.91,;8.37,2.68,)|
Structure:
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