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Target
D(3) dopamine receptor
Ligand
BDBM435388
Substrate
n/a
Meas. Tech.
[3H]-Spiperone Binding Assay
Ki
2.14±n/a nM
Citation
 Cremonesi, S; Micheli, F; Semeraro, T; Tarsi, L Substituted 3,6-diazabicyclo[3.2.0]heptanes US Patent  US10584135 Publication Date 3/10/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM435388
Synonyms:
US10584135, Example 219
Type:
Small organic molecule
Emp. Form.:
C25H34F3N5OS
Mol. Mass.:
509.631
SMILES:
Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |r,w:27.31,31.35,wD:13.12,9.9,(4.11,-7.58,;4.29,-6.05,;3.17,-5.01,;1.68,-5.4,;.59,-4.31,;-.9,-4.71,;-1.99,-3.62,;-3.47,-4.02,;-4.38,-2.78,;-5.84,-3.25,;-7.31,-2.78,;-8.21,-4.02,;-7.31,-5.27,;-5.84,-4.79,;-4.38,-5.27,;-7.79,-6.73,;-9.29,-7.05,;-9.77,-8.52,;-8.75,-9.72,;-7.23,-9.34,;-6.75,-7.88,;-9.23,-11.18,;-9.71,-12.64,;-10.69,-10.7,;-7.76,-11.66,;3.82,-3.61,;5.34,-3.8,;5.64,-5.31,;7.04,-5.96,;7.04,-7.5,;8.37,-8.27,;9.7,-7.5,;11.04,-8.27,;9.7,-5.96,;8.37,-5.19,)|
Structure:
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