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Target
D(3) dopamine receptor
Ligand
BDBM435389
Substrate
n/a
Meas. Tech.
[3H]-Spiperone Binding Assay
Ki
1.10±n/a nM
Citation
 Cremonesi, S; Micheli, F; Semeraro, T; Tarsi, L Substituted 3,6-diazabicyclo[3.2.0]heptanes US Patent  US10584135 Publication Date 3/10/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM435389
Synonyms:
US10584135, Example 221
Type:
Small organic molecule
Emp. Form.:
C25H34F3N5OS
Mol. Mass.:
509.631
SMILES:
Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |r,w:27.31,31.35,wD:13.12,9.9,(4.11,-.25,;4.29,1.28,;3.17,2.33,;1.68,1.93,;.59,3.02,;-.9,2.62,;-1.99,3.71,;-3.47,3.31,;-4.38,4.55,;-5.84,4.08,;-7.31,4.55,;-8.21,3.31,;-7.31,2.06,;-5.84,2.54,;-4.38,2.06,;-7.79,.6,;-9.29,.28,;-9.77,-1.19,;-8.75,-2.38,;-7.23,-2.01,;-6.75,-.55,;-9.23,-3.85,;-9.71,-5.31,;-10.69,-3.37,;-7.77,-4.32,;3.82,3.72,;5.34,3.54,;5.64,2.03,;7.04,1.38,;7.04,-.16,;8.37,-.93,;9.7,-.16,;11.04,-.93,;9.7,1.38,;8.37,2.15,)|
Structure:
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