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Target
Chymotrypsin-like protease CTRL-1
Ligand
BDBM441787
Substrate
n/a
Meas. Tech.
Proteasome-Activity Inhibitory Assay
IC50
12.2±n/a nM
Citation
 Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent  US10640533 Publication Date 5/5/2020 
Target
Name:
Chymotrypsin-like protease CTRL-1
Synonyms:
CTRL | CTRL1 | CTRL_HUMAN
Type:
PROTEIN
Mol. Mass.:
28008.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_49606
Residue:
264
Sequence:
MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALPLVTVNQCRQYWGSSITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTWINQVIAYN
  
Inhibitor
Name:
BDBM441787
Synonyms:
US10640533, Identification number CX13-605 | US10640533, Table 1.34
Type:
Small organic molecule
Emp. Form.:
C37H42N6O7S
Mol. Mass.:
714.83
SMILES:
C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1 |r|
Structure:
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