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Target
Chymotrypsin-like protease CTRL-1
Ligand
BDBM50398607
Substrate
n/a
Meas. Tech.
Proteasome-Activity Inhibitory Assay
IC50
124±n/a nM
Citation
 Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent  US10640533 Publication Date 5/5/2020 
Target
Name:
Chymotrypsin-like protease CTRL-1
Synonyms:
CTRL | CTRL1 | CTRL_HUMAN
Type:
PROTEIN
Mol. Mass.:
28008.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_49606
Residue:
264
Sequence:
MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALPLVTVNQCRQYWGSSITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTWINQVIAYN
  
Inhibitor
Name:
BDBM50398607
Synonyms:
ONX 0912 | OPROZOMIB | US10640533, Identification number CX13-709
Type:
Small organic molecule
Emp. Form.:
C25H32N4O7S
Mol. Mass.:
532.609
SMILES:
COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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