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Target
C-X-C chemokine receptor type 1
Ligand
BDBM385543
Substrate
n/a
Meas. Tech.
In Vitro Affinity Assay
IC50
>20±n/a nM
Citation
 Musicki, B; Bhurruth-Alcor, Y Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies US Patent  US10647706 Publication Date 5/12/2020 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM385543
Synonyms:
US10287278, Example 5 | US10647706, Example 5
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O5S2
Mol. Mass.:
510.026
SMILES:
CN=S(C)(=O)c1c(Cl)ccc(Nc2c(N[C@H]([C@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r|
Structure:
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