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Target
Tyrosine-protein kinase BTK
Ligand
BDBM444716
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<10±n/a nM
Citation
 Liao, X; Li, J; Lu, Z; Zhou, Y; Gao, A Bruton's tyrosine kinase inhibitors US Patent  US10662187 Publication Date 5/26/2020 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM444716
Synonyms:
1-((3R)-3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)-7- ((tetrahydrofuran-3-yl) oxy)-1H-pyrazolo[4,3-c]pyridin-1- yl)piperidin-1-yl)prop-2-en-1-one | US10662187, Compound 86 | US10793566, Compound 86
Type:
Small organic molecule
Emp. Form.:
C31H31ClN4O5
Mol. Mass.:
575.055
SMILES:
COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC4CCOC4)cncc23)c1Cl |r|
Structure:
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