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Target
Proto-oncogene Wnt-1
Ligand
BDBM445794
Substrate
n/a
Meas. Tech.
Wnt activity assay
IC50
69.0±n/a nM
Citation
 Hood, J; Kumar KC, S; Wallace, DM; Mittapalli, GK; Hofilena, BJ; Mak, CC; Bollu, V; Eastman, B 5-substituted indazole-3-carboxamides and preparation and use thereof US Patent  US10669240 Publication Date 6/2/2020 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM445794
Synonyms:
US10669240, Compound 90
Type:
Small organic molecule
Emp. Form.:
C21H25N5O
Mol. Mass.:
363.4561
SMILES:
CC(C)N1CCC(CC1)NC(=O)c1n[nH]c2ccc(cc12)-c1cccnc1
Structure:
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