Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM404505
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay/Biochemical Fluorescence Intensity Assay
IC50
<100±n/a nM
Citation
 Jones, A; Kemp, M; Stockley, M; Gibson, K; Whitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US10689345 Publication Date 6/23/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM404505
Synonyms:
(R)-N-(1-cyanopyrrolidin-3-yl)-N-methyl-5-(1-methyl-1H-pyrazol-4-yl)-1H-indole-2-carboxamide | US10343992, Example 157 | US10689345, Example 157 | US11053198, Example 157 | US11066365, Example 157 | US11390584, Example 262
Type:
Small organic molecule
Emp. Form.:
C19H20N6O
Mol. Mass.:
348.4017
SMILES:
CN([C@@H]1CCN(C1)C#N)C(=O)c1cc2cc(ccc2[nH]1)-c1cnn(C)c1 |r|
Structure:
Search PDB for entries with ligand similarity: