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Target
Interleukin-1 beta
Ligand
BDBM398106
Substrate
n/a
Meas. Tech.
IL-1beta Release Assay
IC50
<10±n/a nM
Citation
 Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent  US10676433 Publication Date 6/9/2020 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM398106
Synonyms:
Preparations of 4-chloro-N-((4,4-difluorocyclohexyl)methyl)-1-(2-methoxyethyl)-1H-indole-3-carboxamide | US10323000, Compound 41 | US10676433, Compound 41
Type:
Small organic molecule
Emp. Form.:
C19H23ClF2N2O2
Mol. Mass.:
384.848
SMILES:
COCCn1cc(C(=O)NCC2CCC(F)(F)CC2)c2c(Cl)cccc12
Structure:
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