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Target
Aurora kinase A
Ligand
BDBM357015
Substrate
n/a
Meas. Tech.
Caliper Kinase Assay
IC50
39840±n/a nM
Citation
 Johnson, JA; Lloyd, J; Finlay, H; Neels, J; Dhondi, NK; Gunaga, P; Banerjee, A; Adisechan, A Quinazolines as potassium ion channel inhibitors US Patent  US10676460 Publication Date 6/9/2020 
Target
Name:
Aurora kinase A
Synonyms:
AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6
Type:
Enzyme
Mol. Mass.:
44791.66
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQKLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
  
Inhibitor
Name:
BDBM357015
Synonyms:
US10214511, Example 19 | US10676460, Example 19
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4
Mol. Mass.:
346.813
SMILES:
Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1
Structure:
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