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Target
Aurora kinase B
Ligand
BDBM357015
Substrate
n/a
Meas. Tech.
Caliper Kinase Assay
IC50
39840±n/a nM
Citation
 Johnson, JA; Lloyd, J; Finlay, H; Neels, J; Dhondi, NK; Gunaga, P; Banerjee, A; Adisechan, A Quinazolines as potassium ion channel inhibitors US Patent  US10676460 Publication Date 6/9/2020 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM357015
Synonyms:
US10214511, Example 19 | US10676460, Example 19
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4
Mol. Mass.:
346.813
SMILES:
Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1
Structure:
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