Reaction Details Report a problem with these data
Target
Protein S100-A9
Ligand
BDBM299065
Substrate
n/a
Meas. Tech.
S100A9-RAGE inhibition assay
IC50
1200±n/a nM
Citation
 Fritzson, I; Liberg, D; East, S; Mackinnon, C; Prevost, N N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors US Patent  US10125125 Publication Date 11/13/2018 
Target
Name:
Protein S100-A9
Synonyms:
CAGB | CFAG | Calgranulin-B | Calprotectin L1H subunit | Leukocyte L1 complex heavy chain | MRP-14 | MRP14 | Migration inhibitory factor-related protein 14 | S100 calcium-binding protein A9 | S100A9 | S10A9_HUMAN | p14
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13239.84
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
114
Sequence:
MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP
  
Inhibitor
Name:
BDBM299065
Synonyms:
2,5-dichloro-N-(6-chloro-4-hydroxypyridin-3-yl)thiophene-3-sulfonamide | US10125125, Example 73
Type:
Small organic molecule
Emp. Form.:
C9H5Cl3N2O3S2
Mol. Mass.:
359.637
SMILES:
Oc1cc(Cl)ncc1NS(=O)(=O)c1cc(Cl)sc1Cl
Structure:
Search PDB for entries with ligand similarity: