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Target
Serine/threonine-protein kinase 24
Ligand
BDBM451730
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
120±n/a nM
Citation
 Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent  US10710978 Publication Date 7/14/2020 
Target
Name:
Serine/threonine-protein kinase 24
Synonyms:
MST3 | STK24 | STK24_HUMAN | STK3
Type:
PROTEIN
Mol. Mass.:
49300.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774397
Residue:
443
Sequence:
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
  
Inhibitor
Name:
BDBM451730
Synonyms:
4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3-yl)-N- cyclopropyl-3-fluoro-N- methylbenzenesulfonamide | US10710978, Compound I-28
Type:
Small organic molecule
Emp. Form.:
C24H23FN4O3S
Mol. Mass.:
466.528
SMILES:
CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Structure:
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