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Target
Serine/threonine-protein kinase 24
Ligand
BDBM451735
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
>1000±n/a nM
Citation
 Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent  US10710978 Publication Date 7/14/2020 
Target
Name:
Serine/threonine-protein kinase 24
Synonyms:
MST3 | STK24 | STK24_HUMAN | STK3
Type:
PROTEIN
Mol. Mass.:
49300.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774397
Residue:
443
Sequence:
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
  
Inhibitor
Name:
BDBM451735
Synonyms:
6-(2-amino-5-(4-ethynyl-2- fluoro-5-nitrophenyl)pyridin- 3-yl)-3,4-dihydroisoquinolin- 1(2H)-one | US10710978, Compound I-45
Type:
Small organic molecule
Emp. Form.:
C22H15FN4O3
Mol. Mass.:
402.3779
SMILES:
Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(c(cc1F)C#C)[N+]([O-])=O
Structure:
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