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Target
Serine/threonine-protein kinase 26
Ligand
BDBM451742
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
>1000±n/a nM
Citation
 Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent  US10710978 Publication Date 7/14/2020 
Target
Name:
Serine/threonine-protein kinase 26
Synonyms:
MASK | MST4 | STK26 | STK26_HUMAN | Serine/threonine-protein kinase MST4
Type:
PROTEIN
Mol. Mass.:
46517.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510631
Residue:
416
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
  
Inhibitor
Name:
BDBM451742
Synonyms:
4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3-yl)-N- cyclohexyl-3-methoxy-N- methylbenzenesulfonamide | US10710978, Compound I-52
Type:
Small organic molecule
Emp. Form.:
C28H32N4O4S
Mol. Mass.:
520.643
SMILES:
COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CCCCC1
Structure:
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