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Target
Serine/threonine-protein kinase 3
Ligand
BDBM451766
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<40±n/a nM
Citation
 Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent  US10710978 Publication Date 7/14/2020 
Target
Name:
Serine/threonine-protein kinase 3
Synonyms:
KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
56284.87
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
491
Sequence:
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
  
Inhibitor
Name:
BDBM451766
Synonyms:
4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3-yl)-N- cyclopropyl-3-methoxy-N- methylbenzenesulfonamide | US10710978, Compound I-72
Type:
Small organic molecule
Emp. Form.:
C25H26N4O4S
Mol. Mass.:
478.563
SMILES:
COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1
Structure:
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