Reaction Details Report a problem with these data
Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM95323
Substrate
n/a
Meas. Tech.
High-Throughput Screening Assay
Kd
0.550±0.05 nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent  US10729695 Publication Date 8/4/2020 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM95323
Synonyms:
4-[4-(2-methoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]morpholine | 4-[4-(2-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]morpholine | MLS000044539 | SMR000022316 | US10729695, Compound CB-7 | cid_2989573
Type:
Small organic molecule
Emp. Form.:
C16H16F3N3O2
Mol. Mass.:
339.3123
SMILES:
COc1ccccc1-c1cc(nc(n1)N1CCOCC1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: