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Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM453281
Substrate
n/a
Meas. Tech.
High-Throughput Screening Assay
Kd
1.40±0.3 nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent  US10729695 Publication Date 8/4/2020 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM453281
Synonyms:
US10729695, Compound CB-14
Type:
Small organic molecule
Emp. Form.:
C13H12BrNO
Mol. Mass.:
278.144
SMILES:
Oc1ccc(NCc2ccc(Br)cc2)cc1
Structure:
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