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Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM453283
Substrate
n/a
Meas. Tech.
High-Throughput Screening Assay
Kd
10000±n/a nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent  US10729695 Publication Date 8/4/2020 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM453283
Synonyms:
US10729695, Compound CD-21
Type:
Small organic molecule
Emp. Form.:
C18H20F3N3O
Mol. Mass.:
351.3661
SMILES:
COc1ccccc1-c1cc(nc(NC2CCCCC2)n1)C(F)(F)F
Structure:
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