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Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM453285
Substrate
n/a
Meas. Tech.
High-Throughput Screening Assay
Kd
6.50±1 nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent  US10729695 Publication Date 8/4/2020 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM453285
Synonyms:
US10729695, Compound CB-2
Type:
Small organic molecule
Emp. Form.:
C13H9F3O3
Mol. Mass.:
270.204
SMILES:
FC(F)(F)c1cc(=O)oc2cc(OCC=C)ccc12
Structure:
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