Reaction Details Report a problem with these data
Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM50249577
Substrate
n/a
Meas. Tech.
High-Throughput Screening Assay
Kd
2.00±1 nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent  US10729695 Publication Date 8/4/2020 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM50249577
Synonyms:
CHEMBL4072531 | US10729695, Compound CB-4
Type:
Small organic molecule
Emp. Form.:
C18H17N3O
Mol. Mass.:
291.3471
SMILES:
OC(Cn1ccc2ccccc12)Cn1cnc2ccccc12
Structure:
Search PDB for entries with ligand similarity: