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Target
D(1A) dopamine receptor
Ligand
BDBM453278
Substrate
n/a
Meas. Tech.
Dopamine D1 Receptor Agonism
EC50
2700±n/a nM
Citation
 Jensen, KG; Kværnø, L; Jørgensen, M; Juhl, M Catecholamine prodrugs for use in the treatment of Parkinson's disease US Patent  US10729710 Publication Date 8/4/2020 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM453278
Synonyms:
US10729710, Compound (Id-ia)
Type:
Small organic molecule
Emp. Form.:
C22H31NO8
Mol. Mass.:
437.4834
SMILES:
CCCN1CCC[C@@H]2Cc3c(C[C@@H]12)ccc(O)c3O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O |r|
Structure:
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