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Target
Aquaporin-9
Ligand
BDBM454617
Substrate
n/a
Meas. Tech.
Calcein Quenching Fluostar Assay
EC50
66.0±n/a nM
Citation
 Evenas, J; Larsson, J; Dreisch, K Compounds for modulating aquaporins US Patent  US10730865 Publication Date 8/4/2020 
Target
Name:
Aquaporin-9
Synonyms:
AQP-9 | AQP9 | AQP9_HUMAN | Aquaglyceroporin-9 | SSC1 | Small solute channel 1
Type:
Protein
Mol. Mass.:
31433.73
Organism:
Human
Description:
O43315
Residue:
295
Sequence:
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
  
Inhibitor
Name:
BDBM454617
Synonyms:
US10730865, Example 8
Type:
Small organic molecule
Emp. Form.:
C17H20N6O3S3
Mol. Mass.:
452.574
SMILES:
CCc1nnc(SCC(=O)Nc2nnc(s2)-c2ccc(cc2)S(C)(=O)=O)n1CC
Structure:
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