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Target
Aquaporin-9
Ligand
BDBM454618
Substrate
n/a
Meas. Tech.
Calcein Quenching Fluostar Assay
EC50
87.0±n/a nM
Citation
 Evenas, J; Larsson, J; Dreisch, K Compounds for modulating aquaporins US Patent  US10730865 Publication Date 8/4/2020 
Target
Name:
Aquaporin-9
Synonyms:
AQP-9 | AQP9 | AQP9_HUMAN | Aquaglyceroporin-9 | SSC1 | Small solute channel 1
Type:
Protein
Mol. Mass.:
31433.73
Organism:
Human
Description:
O43315
Residue:
295
Sequence:
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
  
Inhibitor
Name:
BDBM454618
Synonyms:
US10730865, Example 9
Type:
Small organic molecule
Emp. Form.:
C23H21FN6O2S
Mol. Mass.:
464.515
SMILES:
CCn1c(SCC(=O)Nc2ccc(nn2)-c2ccc(OC)cc2)nnc1-c1ccc(F)cc1
Structure:
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