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Target
Aquaporin-9
Ligand
BDBM454632
Substrate
n/a
Meas. Tech.
Calcein Quenching Fluostar Assay
EC50
39.0±n/a nM
Citation
 Evenas, J; Larsson, J; Dreisch, K Compounds for modulating aquaporins US Patent  US10730865 Publication Date 8/4/2020 
Target
Name:
Aquaporin-9
Synonyms:
AQP-9 | AQP9 | AQP9_HUMAN | Aquaglyceroporin-9 | SSC1 | Small solute channel 1
Type:
Protein
Mol. Mass.:
31433.73
Organism:
Human
Description:
O43315
Residue:
295
Sequence:
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
  
Inhibitor
Name:
BDBM454632
Synonyms:
US10730865, Example 23
Type:
Small organic molecule
Emp. Form.:
C20H26N6O3S2
Mol. Mass.:
462.589
SMILES:
CCn1c(CCOC)nnc1SCC(=O)Nc1nnc(s1)-c1ccc(OC(C)C)cc1
Structure:
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