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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM454909
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay (1% DMSO)
IC50
169±n/a nM
Citation
 Crew, AP; Crews, CM; Chen, X; Dong, H; Ferraro, C; Qian, Y; Siu, K; Wang, J; Jin, M; Berlin, M; Zimmermann, K; Snyder, L Compounds and methods for the enhanced degradation of targeted proteins US Patent  US10730870 Publication Date 8/4/2020 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM454909
Synonyms:
US10730870, Example 76 | US11512083, Example 76
Type:
Small organic molecule
Emp. Form.:
C32H40N4O5S
Mol. Mass.:
592.749
SMILES:
COc1ccc(CCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)cc1 |r|
Structure:
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