Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM455870
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<50±n/a nM
Citation
 Pan, J; Wang, X; Barbosa, J; Yao, W; Ye, Y Heterocyclic compounds and uses thereof US Patent  US10723705 Publication Date 7/28/2020 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM455870
Synonyms:
4-(3-(cyclopropylethynyl)-2- (1-(hydroxyamino)-1-oxo-3- phenylpropan-2-yl)-2H- indazol-5-yl)benzamide | US10723705, No. I-0026
Type:
Small organic molecule
Emp. Form.:
C28H24N4O3
Mol. Mass.:
464.5152
SMILES:
NC(=O)c1ccc(cc1)-c1ccc2nn(C(Cc3ccccc3)C(=O)NO)c(C#CC3CC3)c2c1
Structure:
Search PDB for entries with ligand similarity: