Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM455877
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
125±n/a nM
Citation
Pan, J; Wang, X; Barbosa, J; Yao, W; Ye, Y Heterocyclic compounds and uses thereof US Patent US10723705 Publication Date 7/28/2020
More Info.:
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
Inhibitor
Name:
BDBM455877
Synonyms:
(Z)-N-hydroxy-2-(5- (4-(N'-hydroxy- carbamimidoyl)phen- yl)-2H-indazol-2-yl)- 3-phenylpropanamide | US10723705, No. I-0033
Type:
Small organic molecule
Emp. Form.:
C23H21N5O3
Mol. Mass.:
415.4445
SMILES:
N\C(=N/O)c1ccc(cc1)-c1ccc2nn(cc2c1)C(Cc1ccccc1)C(=O)NO