Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM455983
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<50±n/a nM
Citation
Pan, J; Wang, X; Barbosa, J; Yao, W; Ye, Y Heterocyclic compounds and uses thereof US Patent US10723705 Publication Date 7/28/2020
More Info.:
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
Inhibitor
Name:
BDBM455983
Synonyms:
4-(3- (cyclopropylethynyl)-2- (1-(hydroxyamino)-1- oxo-3-phenylpropan-2- yl)-2H-pyrazolo[3,4- c]pyridin-7-yl)benzamide | US10723705, No. I-0140
Type:
Small organic molecule
Emp. Form.:
C27H23N5O3
Mol. Mass.:
465.5032
SMILES:
NC(=O)c1ccc(cc1)-c1nccc2c(C#CC3CC3)n(nc12)C(Cc1ccccc1)C(=O)NO