Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM456002
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<50±n/a nM
Citation
 Pan, J; Wang, X; Barbosa, J; Yao, W; Ye, Y Heterocyclic compounds and uses thereof US Patent  US10723705 Publication Date 7/28/2020 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM456002
Synonyms:
3-(3-(cyclopropylethynyl)-2- (1-(hydroxyamino)-1-oxo-3- phenylpropan-2-yl)-2H- indazol-7-yl)-N,N- dimethylbenzamide | US10723705, No. I-0159
Type:
Small organic molecule
Emp. Form.:
C30H28N4O3
Mol. Mass.:
492.5683
SMILES:
CN(C)C(=O)c1cccc(c1)-c1cccc2c(C#CC3CC3)n(nc12)C(Cc1ccccc1)C(=O)NO
Structure:
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