Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM456008
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<50±n/a nM
Citation
Pan, J; Wang, X; Barbosa, J; Yao, W; Ye, Y Heterocyclic compounds and uses thereof US Patent US10723705 Publication Date 7/28/2020
More Info.:
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
Inhibitor
Name:
BDBM456008
Synonyms:
2-(3-(cyclopropylethynyl)-7- (1-(2-methoxyethyl)-3- methyl-1H-pyrazol-4-yl)-2H- indazol-2-yl)-N-hydroxy-3- phenylpropanamide | US10723705, No. I-0165
Type:
Small organic molecule
Emp. Form.:
C28H29N5O3
Mol. Mass.:
483.5616
SMILES:
COCCn1cc(c(C)n1)-c1cccc2c(C#CC3CC3)n(nc12)C(Cc1ccccc1)C(=O)NO