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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM456280
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
21.0±n/a nM
Citation
 Gunaga, P; Bhide, RS; Bora, RO; Panda, M; Yadav, ND; Priestley, ES; Richter, J Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors US Patent  US10723723 Publication Date 7/28/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM456280
Synonyms:
6-(4-(((1-hydroxy-1-(4- methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)propan-2- yl)amino)methyl)-1H- 1,2,3-triazol-1-yl)-4- methoxynicotinonitrile (Diastereomer- I: Enantiomer-I) | US10723723, Example 91-I
Type:
Small organic molecule
Emp. Form.:
C22H22N6O4
Mol. Mass.:
434.4479
SMILES:
COc1cc(ncc1C#N)-n1cc(CNC(C)C(O)c2ccc3C(=O)OCc3c2C)nn1
Structure:
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