Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM456281
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
11.0±n/a nM
Citation
 Gunaga, P; Bhide, RS; Bora, RO; Panda, M; Yadav, ND; Priestley, ES; Richter, J Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors US Patent  US10723723 Publication Date 7/28/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM456281
Synonyms:
US10723723, Example 6-I
Type:
Small organic molecule
Emp. Form.:
C25H24N4O5
Mol. Mass.:
460.4819
SMILES:
CN(C[C@H](O)c1ccc2oc(=O)n(C)c2c1)Cc1ccc(nc1)-c1ccc2oc(=O)n(C)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: