Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50248261
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
64.0±n/a nM
Citation
 Chen, D; Song, HY; Sun, ET; Yu, N; Zou, Y Benzimidazole derivatives: preparation and pharmaceutical applications US Patent  US10736881 Publication Date 8/11/2020 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50248261
Synonyms:
CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-isobutyl-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 21 | US10736881, Compound 21 | US8551988, 21
Type:
Small organic molecule
Emp. Form.:
C17H23N3O3
Mol. Mass.:
317.3828
SMILES:
CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Structure:
Search PDB for entries with ligand similarity: