Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50248573
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
167±n/a nM
Citation
 Chen, D; Song, HY; Sun, ET; Yu, N; Zou, Y Benzimidazole derivatives: preparation and pharmaceutical applications US Patent  US10736881 Publication Date 8/11/2020 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50248573
Synonyms:
CHEMBL464719 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-trimethoxybenzyl)-1H-benzo[d]imidazol-5-yl)propanamide | US10201527, Compound 45 | US10736881, Compound 45
Type:
Small organic molecule
Emp. Form.:
C28H31N3O5
Mol. Mass.:
489.5628
SMILES:
COc1cc(Cn2c(CCc3ccccc3)nc3cc(CCC(=O)NO)ccc23)cc(OC)c1OC
Structure:
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