Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM457079
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
9.00±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM457079
Synonyms:
Cis-5-(cyclopropylmethyl)-2- (dimethylamino)-2-(3- fluorophenyl)-7-[2-(oxetan-3- yl)ethyl]-5,7- diazaspiro[3.4]octan-6-one | US10738015, Example SC-47
Type:
Small organic molecule
Emp. Form.:
C23H32FN3O2
Mol. Mass.:
401.5175
SMILES:
CN(C)[C@]1(C[C@@]2(C1)CN(CCC1COC1)C(=O)N2CC1CC1)c1cccc(F)c1 |r,wU:3.2,wD:5.4,(3.33,3.74,;3.73,2.26,;5.22,1.86,;2.64,1.17,;1.55,.08,;.46,1.17,;1.55,2.26,;-.44,2.41,;-1.91,1.94,;-3.24,2.71,;-4.57,1.94,;-5.91,2.71,;-6.31,4.19,;-7.79,3.8,;-7.4,2.31,;-1.91,.4,;-3.15,-.51,;-.44,-.08,;.03,-1.54,;-1,-2.69,;-2.46,-3.16,;-1.32,-4.19,;3.73,.08,;3.33,-1.41,;4.42,-2.5,;5.91,-2.1,;6.31,-.61,;7.79,-.21,;5.22,.48,)|
Structure:
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