Reaction Details Report a problem with these data
Target
Ataxin-1
Ligand
BDBM457113
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
13.0±n/a nM
Citation
Hert, J; Hunziker, D; Mattei, P; Rudolph, M; Schmitz, P; Ullmer, C Bicyclic compounds as dual ATX/CA inhibitors US Patent US10738053 Publication Date 8/11/2020
More Info.:
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Inhibitor
Name:
BDBM457113
Synonyms:
US10738053, Example 4.00 | US10738053, Example 4.01 | US10738053, Example 4.02 | US10738053, Example 4.03 | US10738053, Example 5.00 | US10738053, Example 5.01 | US10738053, Example 5.02 | US10738053, Example 5.03
Type:
Small organic molecule
Emp. Form.:
C23H24F3N3O6S
Mol. Mass.:
527.513
SMILES:
C[C@@]12CN(C[C@H]1CN(C2)C(=O)c1ccc(cc1)S(N)(=O)=O)C(=O)OCc1ccc(OC(F)(F)F)cc1 |r|