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Target
Cyclic GMP-AMP synthase [155-522]
Ligand
BDBM457226
Substrate
n/a
Meas. Tech.
Biochemical Activity Assay
IC50
<20±n/a nM
Citation
 Ndubaku, CO; Katibah, GE; Roberts, TC; Sung, L; Ciblat, S; Raeppel, F; Ly, VL; Ramtohul, YK; Rybak, T; Zaky, M; Gillard, L; Ismaili, H Pyrazolopyrimidinone compounds and uses thereof US Patent  US10738056 Publication Date 8/11/2020 
Target
Name:
Cyclic GMP-AMP synthase [155-522]
Synonyms:
C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase (CGAS) (155-522) | MB21D1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43018.25
Organism:
Homo sapiens (Human)
Description:
Q8N884[155-522]
Residue:
368
Sequence:
RRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
  
Inhibitor
Name:
BDBM457226
Synonyms:
US10738056, Compound A1094
Type:
Small organic molecule
Emp. Form.:
C21H16F3N5O3
Mol. Mass.:
443.3786
SMILES:
COc1cncc(NC(=O)c2c(C)[nH]c3c(c(nn3c2=O)C(F)(F)F)-c2ccccc2)c1
Structure:
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