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Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM457792
Substrate
n/a
Meas. Tech.
3H-cGAMP Filtration Binding Assay
EC50
<1.000±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Childers, ML; Cumming, JN; Haidle, AM; Henderson, TJ; Jewell, JP; Lu, M; Northrup, AB; Otte, RD; Siu, T; Trotter, BW; Truong, QT Cyclic di-nucleotide compounds as STING agonists US Patent  US10738074 Publication Date 8/11/2020 
Target
Name:
Stimulator of interferon genes protein [H232R]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (H232R) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42215.19
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM457792
Synonyms:
9,9′-[(1R,6R,8R,9R,14R,16R,17R,18R)-17,18-dihydroxy-3,11-dioxido-3,11-disulfanyl-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.16,9]-octadecane-8,16-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (Diastereomers 1 and 2) | US10738074, Example 25 | US10738074, Example 26
Type:
Small organic molecule
Emp. Form.:
C20H24N10O12P2S2
Mol. Mass.:
722.542
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)O[C@@H]3[C@H](O)[C@@H](COP(S)(=O)O[C@@H]1[C@@H]2O)O[C@H]3n1cnc2c1nc(N)[nH]c2=O |r|
Structure:
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