Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 9
Ligand
BDBM457999
Substrate
n/a
Meas. Tech.
Evaluation of GLUT9 Inhibitory Activity
IC50
91.8±n/a nM
Citation
 Nagamori, H; Nishimaru, T; Takagi, M; Mitani, I; Nakagawa, Y Nitrogen-containing heteroaryl compound and pharmaceutical use thereof US Patent  US10752596 Publication Date 8/25/2020 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 9
Synonyms:
GLUT-9 | GLUT9 | GTR9_HUMAN | Glucose transporter type 9 | SLC2A9 | Urate transporter
Type:
Protein
Mol. Mass.:
58714.71
Organism:
Human
Description:
Q9NRM0
Residue:
540
Sequence:
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
  
Inhibitor
Name:
BDBM457999
Synonyms:
US10752596, Example 94
Type:
Small organic molecule
Emp. Form.:
C24H26N2O4
Mol. Mass.:
406.4742
SMILES:
COCCCc1cnc(-c2ccc(OC)cc2)c(n1)-c1ccc(CCC(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: