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Target
Tyrosine-protein kinase TXK
Ligand
BDBM458202
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
0.310±n/a nM
Citation
 Laurent, A; Morris, SJ Spirocyclic containing compounds and pharmaceutical uses thereof US Patent  US10752615 Publication Date 8/25/2020 
Target
Name:
Tyrosine-protein kinase TXK
Synonyms:
PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK)
Type:
Protein
Mol. Mass.:
61268.80
Organism:
Homo sapiens (Human)
Description:
P42681
Residue:
527
Sequence:
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
  
Inhibitor
Name:
BDBM458202
Synonyms:
US10752615, Compound 98
Type:
Small organic molecule
Emp. Form.:
C24H24N4O4S
Mol. Mass.:
464.537
SMILES:
COC(=O)c1ccc(s1)C(=O)Nc1nc2ccccc2n1[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C |r,wD:21.23,23.26,(-.44,-6.19,;.97,-5.56,;1.13,-4.03,;2.54,-3.4,;-.11,-3.12,;-1.58,-3.6,;-2.48,-2.35,;-1.58,-1.11,;-.11,-1.58,;-2.05,.36,;-1.02,1.5,;-3.56,.68,;-4.04,2.14,;-5.5,2.62,;-5.5,4.16,;-6.65,5.19,;-6.33,6.7,;-4.86,7.17,;-3.72,6.14,;-4.04,4.63,;-3.13,3.39,;-1.59,3.39,;-.5,2.3,;.59,3.39,;-.5,4.48,;1.49,2.14,;2.96,2.62,;2.96,4.16,;1.49,4.63,;4.2,5.06,;4.04,6.6,;5.61,4.44,;6.86,5.34,)|
Structure:
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