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Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Ligand
BDBM458364
Substrate
n/a
Meas. Tech.
Biochemical Assay for IDH Inhibition
IC50
5750±n/a nM
Citation
 Yang, J Iso-citrate dehydrogenase (IDH) inhibitor US Patent  US10752626 Publication Date 8/25/2020 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Synonyms:
IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46607.23
Organism:
Homo sapiens (Human)
Description:
O75874[R132C]
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM458364
Synonyms:
US10752626, Compound 20
Type:
Small organic molecule
Emp. Form.:
C23H22FN3O2
Mol. Mass.:
391.4381
SMILES:
CCN1Cc2c(ccnc2N[C@@H](C)c2ccc(Oc3ccc(F)cc3)cc2)C1=O |r|
Structure:
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