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Target
Ceramide glucosyltransferase
Ligand
BDBM367647
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
5.5±n/a nM
Citation
 Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent  US10759769 Publication Date 9/1/2020 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM367647
Synonyms:
8-chloro-N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-1H- thieno[3',2':3,4]benzo[1,2- d][1,2]oxazine-4-carboxamide | US10227312, Example 32 | US10759769, Example 32
Type:
Small organic molecule
Emp. Form.:
C27H27Cl2N3O4S
Mol. Mass.:
560.492
SMILES:
O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2c1ccc1sc(Cl)cc21)c1ccc(OC2CC2)c(Cl)c1 |r,t:13|
Structure:
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