Reaction Details Report a problem with these data
Target
Ubiquitin-like modifier-activating enzyme 6
Ligand
BDBM299242
Substrate
n/a
Meas. Tech.
UBA6 AlphaScreen Assay
IC50
<50±n/a nM
Citation
 Amidon, BS; Cardin, DP; Gould, AE; Greenspan, PD; Harrison, SJ Indole substituted pyrrolopyrimidinyl inhibitors of Uba6 US Patent  US9593121 Publication Date 3/14/2017 
Target
Name:
Ubiquitin-like modifier-activating enzyme 6
Synonyms:
E1-L2 | MOP-4 | MOP4 | Monocyte protein 4 | UBA6 | UBA6_HUMAN | UBE1L2 | Ubiquitin-activating enzyme 6 | Ubiquitin-activating enzyme E1-like protein 2
Type:
PROTEIN
Mol. Mass.:
117960.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939704
Residue:
1052
Sequence:
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
  
Inhibitor
Name:
BDBM299242
Synonyms:
US9593121, I-05 | {(1S,2S,4R)-4-[4-(6-cyano-1H-indol-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl} methyl
Type:
Small organic molecule
Emp. Form.:
C21H18N5O
Mol. Mass.:
356.4005
SMILES:
[CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(cc2[nH]1)C#N |^1:0|
Structure:
Search PDB for entries with ligand similarity: