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Target
Ubiquitin-like modifier-activating enzyme 6
Ligand
BDBM299257
Substrate
n/a
Meas. Tech.
UBA6 AlphaScreen Assay
IC50
<50±n/a nM
Citation
 Amidon, BS; Cardin, DP; Gould, AE; Greenspan, PD; Harrison, SJ Indole substituted pyrrolopyrimidinyl inhibitors of Uba6 US Patent  US9593121 Publication Date 3/14/2017 
Target
Name:
Ubiquitin-like modifier-activating enzyme 6
Synonyms:
E1-L2 | MOP-4 | MOP4 | Monocyte protein 4 | UBA6 | UBA6_HUMAN | UBE1L2 | Ubiquitin-activating enzyme 6 | Ubiquitin-activating enzyme E1-like protein 2
Type:
PROTEIN
Mol. Mass.:
117960.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939704
Residue:
1052
Sequence:
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
  
Inhibitor
Name:
BDBM299257
Synonyms:
US9593121, I-07 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-methoxy-1H-indol-2-yl)- 7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentyl}methyl
Type:
Small organic molecule
Emp. Form.:
C21H21N4O2
Mol. Mass.:
361.417
SMILES:
[CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(OC)cc2[nH]1 |^1:0|
Structure:
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