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Target
Tyrosine-protein kinase JAK2 [826-1132]
Ligand
BDBM458887
Substrate
n/a
Meas. Tech.
In Vitro JAK kinase Assays
IC50
0.800±n/a nM
Citation
 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent  US10759793 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK2 [826-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35849.63
Organism:
Homo sapiens (Human)
Description:
aa 826-1132
Residue:
307
Sequence:
RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM458887
Synonyms:
US10759793, Example 39
Type:
Small organic molecule
Emp. Form.:
C21H25FN6O4
Mol. Mass.:
444.4594
SMILES:
COCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12
Structure:
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