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Target
Tyrosine-protein kinase JAK3 [795-1124]
Ligand
BDBM458945
Substrate
n/a
Meas. Tech.
In Vitro JAK kinase Assays
IC50
3.00±n/a nM
Citation
 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent  US10759793 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK3 [795-1124]
Synonyms:
JAK3 | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (795-1124)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37299.74
Organism:
Homo sapiens (Human)
Description:
aa 795-1124
Residue:
330
Sequence:
ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM458945
Synonyms:
US10759793, Example 89
Type:
Small organic molecule
Emp. Form.:
C25H23FN8O2
Mol. Mass.:
486.5009
SMILES:
OCc1cncc(c1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12
Structure:
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